venofer dosing calculator

Applies only to oral form of both agents. Avoid or Use Alternate Drug. and formulary information changes. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Access your plan list on any device mobile or desktop. David McAuley, Pharm.D. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. 3. gymnema decreases levels of iron sucrose by inhibition of GI absorption. Minor/Significance Unknown. 1) Ganzoni AM. Slow or stop the infusion if adverse reactions occur. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Use Caution/Monitor. Minor/Significance Unknown. Separate dosing of tetracyclines from these products. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Avoid or Use Alternate Drug. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Found in multiple references. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. provider for the most current information. Minor/Significance Unknown. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. We comply with the HONcode standard for trustworthy health information. Schrier SL, Mentzer WC, Landaw SA. Am J Kid Dis 2001; 38 988991. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. 1988 May;111(5):566-70. prescription products. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Reference www.medicines.org.uk Background Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. This information is not individual medical advice and does not substitute for the advice of your health care professional. Minor/Significance Unknown. Minor/Significance Unknown. 2. Comparable efficacy to that of IV iron sucrose. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. David McAuley, Pharm.D. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Applies only to oral form of both agents. Shirley, NY: American Regent, Inc.; 9/2020. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Applies only to oral form of both agents. Nutrition. Do not administer Venofer to patients with evidence of iron overload. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Kidney Int. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. The dosage of Venofer is expressed in mg of elemental iron. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Applies only to oral form of both agents. Schweiz Med Wochenschr; 100(7):301-3. Copyright 1993-2021 It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. The dosage of Venofer is expressed in mg of elemental iron. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Modify Therapy/Monitor Closely. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. (See also Notes section. It can be expressed in mg per ml. Interaction only with oral iron administration. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Minor/Significance Unknown. Applies only to oral form of both agents. Applies only to oral form of both agents. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Anemia; 2015: 763576. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Consult your doctor before breast-feeding. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Minor/Significance Unknown. 5. Do not administer Venofer to patients with iron overload. Avoid or Use Alternate Drug. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. May increase risk of hypotension. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. 1 ,*. May increase risk of hypotension. Applies only to oral form of both agents. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. iron sucrose, benazepril. Drug class: Iron products. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Applies only to oral form of both agents. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Applies only to oral form of both agents. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. World J Gastroenterol; 16(22): 27202725. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . 2010; 193(9):525-32. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If either is present, do not use the liquid. Available for Android and iOS devices. Avoid or Use Alternate Drug. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. . Either decreases levels of the other by inhibition of GI absorption. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Before using, check this product visually for particles or discoloration. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Fulminant symptoms include confusion, sensation of passing out, paleness. Use Caution/Monitor. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. 1982;13(4):309-21. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. US residents can call their local poison control center at 1-800-222-1222. Schweiz Med Wochenschr. Applies only to oral form of both agents. Applies only to oral form of both agents. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Applies only to oral form of both agents. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. We'll do this entirely for free, as long as the calculator has applications for women's health. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Use Caution/Monitor. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Max Dose. Step 2: Calculation and administration of the maximum individual iron dose(s): . This topic . Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Accessed: 4/12/2011. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Avoid or Use Alternate Drug. MISSED DOSE: It is important to get each dose of this medication as scheduled. Applies only to oral form of both agents. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Applies only to oral form of both agents. 1974 Jun;31(6):592-5. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Your list will be saved and can be edited at any time. Applies only to oral form of both agents. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. May increase risk of hypotension. Either increases effects of the other by pharmacodynamic synergism. *Administer early during the dialysis session. Applies only to oral form of both agents. Applies only to oral form of both agents. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Each costs about $0.46 to $0.55 per mg of iron. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Avoid or Use Alternate Drug. Separate by 2 hr. Use Caution/Monitor. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. Applies only to oral form of both agents. If we don't have the calculator you need we'll try to make it for you and add it to the website. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to . Fulminant symptoms may include general paleness, confusion or episodes of passing out. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Either decreases levels of the other by inhibition of GI absorption. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Venofer treatment may be repeated if iron deficiency reoccurs. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. Venofer must only be administered intravenously either by slow injection or by infusion. 1) Ganzoni AM. Iron deficiency anemia is the type of anemia caused by iron depletion. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. commonly, these are generic drugs. Venofer [package insert]. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Adding plans allows you to compare formulary status to other drugs in the same class. These can be input in g/dL, g/L or mmol/L. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Treatment of anemia due to iron deficiency. Applies only to oral form of both agents. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. This drug is available at a higher level co-pay. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . iron sucrose decreases levels of deferiprone by enhancing GI absorption. Minor/Significance Unknown. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Separate by 2 hr. Minor (1)iron sucrose, captopril. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Applies only to oral form of both agents. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. By using this form you agree with the storage and handling of your data by this website. trientine, iron sucrose. Use Caution/Monitor. Minor/Significance Unknown. Applies only to oral form of both agents. Most Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Avoid or Use Alternate Drug. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Venofer may reduce the absorption of concomitantly administered oral iron preparations. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Slowing the infusion rate may alleviate symptoms. Keep all medical and lab appointments. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . iron sucrose decreases levels of tetracycline by inhibition of GI absorption. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Applies only to oral form of both agents. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. This information does not assure that this product is safe, effective, or appropriate for you. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Otherwise, call a poison control center right away. 1995 Mar-Apr;11(2):163-8. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Copyright 2021 GlobalRPH - Web Development by. 1. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. 1. Drug Des Devel Ther; 5: 5160. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Either increases effects of the other by pharmacodynamic synergism. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Applies only to oral form of both agents. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. Use Caution/Monitor. Applies only to oral form of both agents. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Official Journal of the International Society of Nephrology. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Applies only to oral form of both agents. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Use alternatives if available. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Applies only to oral form of both agents. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW

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